Marshmallow (Althaea officinalis) Root — 110 mg

Marshmallow root has traditionally been used for its mucilaginous properties — primarily for soothing irritated mucosal tissues in the throat and digestive tract. Within NeuroSalt’s materials, this ingredient is positioned as a “protector of irritated nerve tissues” that reduces inflammatory processes. Published research on marshmallow root focuses primarily on its demulcent and anti-inflammatory effects on mucosal surfaces. Published peer-reviewed research specifically evaluating marshmallow root for nerve tissue protection or neuropathic pain relief in human studies appears limited based on available literature.

Corydalis (Corydalis yanhusuo) Powder — 100 mg

Corydalis yanhusuo has perhaps the most substantial published research among the ingredients in this formula for pain-related applications. Within NeuroSalt’s materials, this ingredient is described as a natural analgesic that blocks neuropathic pain signals. In published research, a 2016 study in PLOS ONE by University of California, Irvine researchers systematically evaluated Corydalis yanhusuo extract across multiple standardized pain models and reported that it attenuated acute, inflammatory, and neuropathic pain in animal models without causing tolerance — a notable finding, since tolerance is a significant limitation with many conventional analgesics. The researchers identified dopamine D2 receptor antagonism as a key mechanism. A controlled human trial conducted at the University of Chicago reported that oral administration of Corydalis yanhusuo extract significantly decreased pain intensity scores in a cold-pressor pain model.

Published animal studies typically used YHS at 100–500 mg/kg of body weight. Reports from Chinese clinical research have referenced dosages of 75 mg of the isolated alkaloid tetrahydropalmatine (THP) daily, or 5–10 grams of crude herb equivalent. NeuroSalt provides 100 mg of Corydalis powder per serving — the relationship between this amount and dosages used in published studies depends on factors like extract concentration and alkaloid content, which are not specified on the label.

Safety note: published literature has associated THP with liver-related concerns in some reports. Consumers taking other medications should discuss this ingredient with a healthcare provider.

Prickly Pear (Opuntia phaeacantha) 20:1 Extract — 50 mg

Prickly pear is rich in antioxidant compounds including betalains and polyphenols. Within NeuroSalt’s materials, this ingredient is positioned as combating oxidative stress in nerves. Oxidative stress is a recognized factor in neuropathic conditions within published literature, and prickly pear does demonstrate antioxidant activity in laboratory settings. The 20:1 extract ratio means 50 mg represents a concentrated form. However, published clinical trials specifically evaluating prickly pear extract for nerve protection or neuropathy-related outcomes in humans appear limited.

California Poppy (Eschscholzia californica) Seed — 45 mg

California poppy has traditional use as a mild sedative and analgesic. It contains alkaloids studied for their effects on GABA receptors and pain signaling. Within NeuroSalt’s materials, this ingredient is described as reducing anxiety and muscle tension that amplify nerve pain while improving nighttime rest. Published research, primarily in animal models, suggests mild sedative and pain-modulating properties. At 45 mg per serving, this is the smallest-dosed ingredient in the formula.